Distribution and expression of IL-17 and related cytokines in children with Mycoplasma pneumoniae pneumonia.

In this study, we used FCM (Flow Cytometry) to analyze IL-17 and related cytokines in plasma and bronchoalveolar lavage fluid (BALF) samples from 18 patients with general MPP (GMPP) and 30 patients with refractory MPP (RMPP). The levels of IL-1Ra, IL-6, IL-8, IL-17 and TNF-α were significantly elevated in the BALF of MPP children compared with the plasma (P
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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ConclusionsCarbapenem-based regimen of combination therapy, seems to be an option to treat patients infected withKlebsiella pneumoniae resistant to ceftazidime/avibactam and susceptible to carbapenem, at least when the risk of mortality is low.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Butterfly Network, the digital health unicorn democratizing medical imaging, is continuing to add new applications for its handheld, single probe, smartphone-connected ultrasound technology. The Butterfly iQ, the multi-purpose pocket-sized ultrasound...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Cardiology Critical Care Emergency Medicine Exclusive News Ob/Gyn Pediatrics Radiology Surgery Urology Vascular Surgery Source Type: blogs
Most people aren't aware they can trigger allergy-like symptoms and serious infections such as pneumonia, according to Manal Mohammed, a lecturer in microbiology at Westminster University.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Importance: Hospitals that serve poorer populations have higher readmission rates. It is unknown whether these hospitals effectively lowered readmission rates in response to the Hospital Readmissions Reduction Program (HRRP). Objective: To compare pre-post differences in readmission rates among hospitals with different proportion of dual-eligible patients both generally and among the most highly penalized (ie, low performing) hospitals. Design: Retrospective cohort study using piecewise linear model with estimated hospital-level risk-standardized readmission rates (RSRRs) as the dependent variable and a change poin...
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
Publication date: Available online 13 November 2019Source: Journal of Critical CareAuthor(s): Cédric Carrié, Guillaume Bardonneau, Laurent Petit, Alexandre Ouattara, Didier Gruson, Bruno Pereira, Matthieu BiaisAbstractPurposeTo compare the rate of therapeutic failure in critically ill patients treated by third-generation cephalosporins (3GCs) or piperacillin-tazobactam (PTZ) for wild-type AmpC-producing Enterobacterales pulmonary infections.MethodsOver a 4-year period, all adult patients treated for a wild-type AmpC-producing Enterobacterales pulmonary infection were retrospectively included. Two groups of pa...
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
Publication date: Available online 13 November 2019Source: Clinica Chimica ActaAuthor(s): Julia Oto, Álvaro Fernández-Pardo, Manuel Miralles, Emma Plana, Francisco España, Silvia Navarro, Pilar MedinaAbstractActivated protein C (APC) acts as an “on demand” anticoagulant, reducing thrombin formation. Reduced plasma levels of APC or protein C (PC) are associated with an increased risk of venous thromboembolism. APC also displays cytoprotective functions and its therapeutic use has been evaluated in severe sepsis and is under evaluation in several diseases with an important inflammatory compon...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Let’s pretend the 195 nations that signed the 2016 Paris Climate Accord really do take all of the steps necessary to reach the agreement’s key goal: limiting the increase in global temperature to 1.5°C above pre-industrial levels. In that world, any children born today would grow up to witness some happy milestones. If they lived in the United Kingdom, they’d see their country phase out the use of coal by the time they turned six. If they lived in France, they would see gasoline-powered cars eliminated by their 21st birthday. And, as all of the 195 countries similarly reached their individual targets,...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Children climate change embargoed study Environment global warming health Source Type: news
ConclusionsOur study indicated that there is substantial scope for improvement in prescribing patterns at Damanhour Medical National Institute that could be achieved by adhering to standard guidelines of treatment and restriction policies to promote rationality of drug use.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
The introduction of antifibrotic agents to clinical practice and the need to better define patient populations for future clinical trials highlight the importance of accurate diagnosis. The main unmet need lies within the population of patients with fibrotic interstitial lung disease (f-ILD) and indeterminate for usual interstitial pneumonia (UIP) pattern on high-resolution computed tomography (HRCT). The differential diagnosis mainly includes idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), ILD associated with occult collagen tissue disease and, most notably, chronic hypersensitivity pneumonitis.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Pseudomonas aeruginosa is an opportunistic bacterium associated with healthcare infections in intensive care units (ICUs), ventilator-associated pneumonia (VAP), surgical site infections, and burns. This bacterium causes 75% of death in burned patients, since it can develop a persistent biofilm associated with infections, express several virulence factors, and antibiotic-resistance mechanisms. Some of these virulence factors are proteases such as elastase and alkaline protease, or toxic metabolites such as pyocyanin and is one of the few microorganisms able to produce cyanide, which inhibits the cytochrome oxidase of host ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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