Alpha-1-Acid Glycoprotein 1 is Upregulated in Pancreatic Ductal Adenocarcinoma and Confers a Poor Prognosis

Pancreatic cancer is an aggressive malignancy that carries a high mortality rate. A major contributor to the poor outcome is the lack of effective molecular markers. The purpose of this study was to develop protein markers for improved prognostication and non-invasive diagnosis. A mass spectrometry (MS)-based discovery approach was applied to pancreatic cancer tissues and healthy pancreas. In the verification phase, extracellular proteins with differential expression were further quantified in targeted mode using parallel reaction monitoring (PRM).

Source: Translational Research - June 27, 2019 Category: Research Authors: Qimin Zhou, Roland Andersson, Dingyuan Hu, Monika Bauden, Agata Sasor, Thomas Bygott, Krzysztof Pawlowski, Indira Pla, Gy örgy Marko-Varga, Daniel Ansari Tags: Original article Source Type: research