Prednisolone treatment induced temporary Factor IX normalization in mild hemophilia B who required an epidural infiltration: a case report

A 31-year-old man with mild hemophilia B developed a herniated disc treated with prednisolone for back pain. Surprisingly, hemostasis result tests performed before epidural infiltration were a normal activated partial thrombin time at 36.1  s. (normal range 27.9-37.7 s.) and factor IX (FIX) level 76% (normal range>70%), 13 days after prednisolone introduction. After a second control with a normal FIX level and a second genetic confirmation of hemophilia, no FIX concentrates was administered to perform the infiltration, which occurred without hemorrhagic complication.

Source: Transfusion and Apheresis Science - June 27, 2019 Category: Hematology Authors: M. Carrette, G. Feugray, P. Chamouni, V. Le Cam Duchez, M. Fretigny, V. Barbay, P. Billoir Source Type: research