A genome-wide association study implicates NR2F2 in lymphangioleiomyomatosis pathogenesis

Conclusions
SNPs on chromosome 15q26.2 are associated with S-LAM, and chromatin and expression data suggest that this association may occur through effects on NR2F2 expression, which potentially plays an important role in S-LAM development.

Source: European Respiratory Journal - June 26, 2019 Category: Respiratory Medicine Authors: Kim, W., Giannikou, K., Dreier, J. R., Lee, S., Tyburczy, M. E., Silverman, E. K., Radzikowska, E., Wu, S., Wu, C.-L., Henske, E. P., Hunninghake, G., Carel, H., Roman, A., Pujana, M. A., Moss, J., Won, S., Kwiatkowski, D. J. Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung disease and rare lung disease Source Type: research