The maternal and paternal effects on clinical and surgical definitions of osteoarthritis
ConclusionOA in the mother increased the risk of surgical and clinical definitions of hip, knee and hand OA in the offspring and particularly in daughters. Our findings imply that heredity of OA may be linked to maternal genes and/or maternal ‐specific factors such as the fetal environment.This article is protected by copyright. All rights reserved.
Authors: Safran MR, Bedi A, Byrd JWT, Guanche CA, Ilizaliturri V, Lynch TS, Martin HD, Matsuda DK, McCarthy JC, Philippon MJ, Sampson TG, Suarez-Ahedo C Abstract Hip arthroscopy is one of the most rapidly growing areas in orthopaedic surgery because of increased awareness of nonarthritic hip pathologies, advanced imaging modalities, and advanced techniques to reproducibly manage nonarthritic hip pathologies within a deep soft-tissue envelope and a constrained joint. In addition, more academic medical centers are providing residents with education on hip arthroscopy, and many hip preservation fellowships and courses...
CONCLUSION: Patients with WD who develop ALF with an NWIS> 11 may survive after treatment with Zn and chelators, without liver transplantation, when they present with mild hyperbilirubinemia and stage ≤ II hepatic encephalopathy. Osteoarthritis symptoms may improve with long-term Zn and chelator therapy without correlation of liver function in WD. PMID: 31388402 [PubMed]
Pain relievers such as ibuprofen and naproxen may account for higher rates of heart disease and stroke in those with osteoarthritis.
In conclusion, with study of the frailty syndrome still in its infancy, frailty analysis remains a major challenge. It is a challenge that needs to be overcome in order to shed light on the multiple mechanisms involved in the pathogenesis of this syndrome. Although several mechanisms contribute to frailty, immune system alteration seems to play a central role: this syndrome is characterized by increased levels of pro-inflammatory markers and the resulting pro-inflammatory status can have negative effects on various organs. Future studies should aim to better clarify the immune system alteration in frailty, and seek to esta...
ConclusionsMore than half of Medicaid beneficiaries receiving an opioid for pain management do so for orthopedic- and dental-related reasons, with emergency department providers more likely to prescribe opioids. Modifications to the guidelines addressing temporary acute pain management practices with opioids would be likely to benefit emergency department providers the most.
In this study, UBX0101 was well-tolerated. Improvement in several clinical outcomes, including pain and function, as well as modulation of certain senescence-associated secretory phenotype (SASP) factors and disease-related biomarkers was observed after a single dose of UBX0101. UNITY plans to initiate a Phase 2 study of UBX0101 in patients with painful, moderate-to-severe OA of the knee. The study is expected to enroll approximately 180 patients with initiation expected in the fourth quarter of 2019 and initial 12-week results expected in the second half of 2020. This will be a randomized, double-blind, placebo-con...
Conditions: Hip Dysplasia; Hip Pain Chronic; Hip Osteoarthritis; Hip Arthritis; Psychosocial Problem Interventions: Device: Cell Phone Based Cognitive Based Therapy (Pacifica App); Other: Control Sponsor: Michael C Willey Not yet recruiting
DISCUSSION: Given the good clinical outcomes after both TSA and RSA, there may be an increased role for RSA in this elderly cohort to provide effective treatment of glenohumeral osteoarthritis. LEVEL OF EVIDENCE: Level III, retrospective comparative study. PMID: 31356423 [PubMed - as supplied by publisher]
Conclusions: This cadaveric study aids in establishing the prevalence of LSTV (12.7%) in a random population and the frequency of the various Castellvi LSTV morphologies. An association was found between type Ia morphology and L4–L5 osteoarthritis which has not been reported in the past, suggesting that mild LSTV may carry more significance to lumbar pathology than previously considered.
Comparison of two doses of bio-optimized Curcuma longa extract (BCL) in the management of symptomatic knee osteoarthritis (OA).