Efficacy and Safety of Brinzolamide as Add-On to Prostaglandin Analogues or β-Blocker for Glaucoma and Ocular Hypertension: A Systematic Review and Meta-Analysis

Conclusions: Brinzolamide, as add-on to PGAs or β-blocker, significantly decrease IOP of patients with refractory glaucoma or OHT and the AEs were tolerable.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Abstract The optic nerve sheath (ONS) is biomechanically important. It is acted on by tension due to ocular movements, and by fluid shifts and/or alterations in intracranial pressure (ICP) in human disease, specifically in pathologies leading to intracranial hypertension. It has also been hypothesized that the ONS is acted on by altered ICP in astronauts exposed chronically to microgravity. However, a non-invasive method to quantify ONS biomechanical properties is not presently available; knowledge of such properties is desirable to allow characterization of the biomechanical forces exerted on the optic nerve head...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Publication date: Available online 21 September 2020Source: Pregnancy HypertensionAuthor(s): Kim J.C. Verschueren, Rubinah R. Paidin, Annabel Broekhuis, Olivier S.S. Ramkhelawan, Lachmi R. Kodan, Humphrey H.H. Kanhai, Joyce L. Browne, Kitty W.M. Bloemenkamp, Marcus J. Rijken
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
CONCLUSIONS: Under a real-life clinical practice setting, SSTS provides effective pain management and is easy to use for patients and nurses. PMID: 32959632 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Wong A, Keith C, Gregory H, Liew D Abstract COVID-19 brings with it unprecedented challenges in clinical management. An important component of care is the provision of safe and effective symptom control. Given the emerging literature reporting on the risk of QT prolongation and arrhythmias associated with COVID-19 disease and experimental therapies, we highlight some considerations for the prescribing of palliative care medications in this context. Based on the experience gained from palliative care referrals at our institution prior to and during the COVID-19 pandemic, and in collaboration with our clinic...
Source: Journal of Pain and Palliative Care Pharmacotherapy - Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research
We report a case of using ketamine as a patient-controlled analgesia (PCA) for the treatment of CPS. A 58-year-old male with CPS presented with severe generalized body pain refractory to multiple pharmacological interventions. He was started on a basal infusion rate at 0.3 mg/kg/h with a ketamine PCA bolus of 10 mg with a 10-minute lockout period. Over the next 7 days, the basal infusion rate was titrated up to 2.1 mg/kg/h relative to the number of times the patient pressed the PCA. At the end of the trial, the patient reported 0/10 pain with lightheadedness on the first day being the only side ...
Source: Journal of Pain and Palliative Care Pharmacotherapy - Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research
We describe a patient suffering from bilateral intracerebral hemorrhage after severe olanzapine intoxication without underlying thrombocytopenia, arterial hypertension, or vascular malformation as cause of intracerebral hemorrhage. This raises the possibility of a direct side effect of high-dose olanzapine intake. So far, intracranial hemorrhage after olanzapine intoxication in such constellation has not been reported before. Given the high number of its prescription rates, our finding of intracranial hemorrhage after olanzapine intoxication is of high clinical relevance. PMID: 32953191 [PubMed]
Source: Case Reports in Psychiatry - Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
Publication date: Available online 22 September 2020Source: American Journal of Orthodontics and Dentofacial OrthopedicsAuthor(s): Federica Altieri, Michele Cassetta
Source: American Journal of Orthodontics and Dentofacial Orthopedics - Category: Dentistry Source Type: research
Publication date: Available online 22 September 2020Source: Acta Pharmaceutica Sinica BAuthor(s): Nur Farah Meor Azlan, Maarten P. Koeners, Jinwei Zhang
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
The overall goals of this workshop are two fold — one is to convene principal investigators funded by NCCIH on the topic of the analgesic properties of minor cannabinoids and terpenes from natural products and the underlying mechanisms; and the other is to discuss current research barriers and opportunities on this topic. This workshop is aligned with NCCIH ’ s mission to support research on the fundamental science, safety, and usefulness of complementary and integrative health approaches. Specifically, minor cannabinoids and terpenes from natural products are part of complementary interventions supported by NC...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Conditions:   Anxiety Postoperative;   Pain, Postoperative;   Vascular Access Site Pain Interventions:   Device: OnComfort autohypnosis;   Other: Treatment as usual, without the OnComfort autohypnosis system Sponsor:   Salah D. Qanadli Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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