Community-acquired serious bacterial infections in the first 90 days of life: a revisit in the era of multi-drug-resistant organisms.

CONCLUSIONS: The bacteriology of SBIs in the first 90 days of life is changing to include more MDROs, which causes more delay in providing targeted antimicrobial therapy. Awareness of the local epidemiology is crucial to ensure appropriate antibiotics are provided in a timely manner. PMID: 31230257 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - Category: Pediatrics Authors: Tags: World J Pediatr Source Type: research

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In this study we inoculated ground chicken meat with 25 individual isolates of clinical uropathogenic E. coli (UPEC) and newborn meningitis causing E. coli (NMEC), isolates from retail chicken meat (CM), as well as retail chicken-skin isolates identified in our laboratory (CS). We then determined their gamma radiation inactivation kinetics (D10-value). The mean D10-value for all isolates (n = 25) was 0.30 kGy. The mean D10-value for the UPEC, NMEC, CM, and CS isolates were 0.25, 0.29, 0.29, and 0.39 kGy, respectively. The mean D10-value for the clinical isolates was 0.27 kGy vs. 0.34 kGy for the non-clinical is...
Source: Food Microbiology - Category: Food Science Authors: Tags: Food Microbiol Source Type: research
In this study, ground chicken meat (GCM) was inoculated three different ExPEC multiisolate cocktails, including Uropathogenic E.coli (UPEC), Neonatal Meningitis causing E.coli (NMEC), and Food-Source (FS) isolates. D10 (55, 60, and 65 °C) (e.g. 7.34, 0.56, 0.05 min, respectively) and z-values (4.62 to 5.89 °C) were found consistent with, or slightly lower than, those of E. coli O157:H7 in low fat meat and poultry. There was little difference in D10 and z-value when ExPEC were recovered on APC Petrifilms versus E. coli Petrifilms. The D10 of 19 individual ExPEC isolates determined at 55 °C ranged from 1.84 to 7....
Source: Food Control - Category: Food Science Source Type: research
Conclusion: New carbapenem/βLI combinations may be viable alternatives to antimicrobial combination therapy as they displayed high efficacy in vitro and in vivo. Meropenem/Avibactam and Meropenem/Relebactam should be tested on larger sample sizes with different carbapenemases before progressing further in its preclinical development. Introduction Carbapenem resistant Gram-negative bacteria have been gradually increasing in prevalence in recent years. In the United States, the latest CDC Antibiotic Resistance Threat Report indicates that Carbapenem-Resistant Enterobacteriaceae (CREs) are responsible for 9,000 a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we sought to establish a new, carefully optimized method to extract and purify non-denatured, native FliC from the reference UPEC strain CFT073 to be suitable for immune assays. To achieve purification of FliC to homogeneity, we used a mutant CFT073 strain containing deletions in four major chaperone-usher fimbriae operons (type 1, F1C and two P fimbrial gene clusters; CFT073Δ4). A sequential flagella extraction method based on mechanical shearing, ultracentrifugation, size exclusion chromatography, protein concentration and endotoxin removal was applied to CFT073Δ4. Protein purity and integrity ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusion This study revealed that Enterococcus species with biofilm potentials and extracellular virulence properties extensively occur in retail RTE shrimps. A significant number of isolated strains are resistant to antibiotics and harbor resistant and virulent genes, denoting a significant route of resistance and virulence dissemination to bacteria in humans. There is an inadequate understanding of the intricacies of antibiotic-resistant enterococci of food origin that belong to enterococci aside from E. faecium and E. faecalis. Findings from this study reveal detailed antibiotic resistance of E. durans, E. casselifla...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 7 August 2018Source: Veterinary MicrobiologyAuthor(s): C.A. Kennedy, C. Walsh, M. Karczmarczyk, S. O’Brien, N. Akasheh, M. Quirke, S. Farrell-Ward, T. Buckley, U. Fogherty, K. Kavanagh, C.T. Parker, T. Sweeney, S. FanningAbstractExtraintestinal pathogenic E. coli (ExPEC) possess the ability to cause extraintestinal infections such as urinary tract infections, neonatal meningitis and sepsis. While information is readily available describing pathogenic E. coli populations in food-producing animals, studies in companion/sports animals such as horses are limited. In addition, many antim...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Escherichia coli is frequently the first bacterium which colonizes human infants. It is a lifelong colonizer of adults too [1]. It also represents the most frequent agent of extra-intestinal infections including urinary tract infection, bacteremia, pneumonia, bone and joint infections, intra-abdominal infections, and meningitis [2]. According to their capacity of intestinal colonization, commensal E. coli strains are divided into two categories; resident strains which have the ability of persistence in their hosts for many months, and transient strains which disappear from the microbiota within some weeks [3].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Tags: Themed Issue: Recent Advances in Antimicrobial and Bacterial Resistance Source Type: research
Publication date: July 2018Source: Saudi Pharmaceutical Journal, Volume 26, Issue 5Author(s): Ahmed G. Abdelhamid, Aliaa Esaam, Mahmoud M. HazaaAbstractThe sharp increase in antibiotic resistance imposes a global threat to human health and the discovery of effective antimicrobial alternatives is needed. The use of probiotics to combat bacterial pathogens has gained a rising interest. Pathogenic Escherichia coli is causative of multiple clinical syndromes such as diarrheal diseases, meningitis and urinary tract infections. In this work, we evaluated the efficacy of probiotics to control multidrug-resistant E. coli and reduc...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Escherichia coli (E. coli) is known to cause urinary tract infection (UTI) and meningitis in neonates, as well as existing as a commensal flora of the human gut. Extended-spectrum β-lactamase (ESBL)-producing E. ...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
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