Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

ConclusionIFN-I induces STAT3 activation to activateGzmb expression to enhance CTL effector function to suppress tumor development. Human colorectal carcinoma may use down-regulation of IFNAR1 on CTLs to suppress CTL effector function to evade host cancer immunosurveillance.

http://link.springer.com/10.1186/s40425-019-0635-8

Source: Journal for Immunotherapy of Cancer - June 21, 2019 Category: Cancer & Oncology Source Type: research