Hypertonic Mannitol for the Prevention of Intradialytic Hypotension: A Randomized Controlled Trial

ConclusionsIn this pilot randomized controlled trial studying patients requiring initiation of HD, we found no difference in absolute SBP decline between those who received mannitol and those who received saline solution. However, there were fewer overall IDH events and a nominally lower risk for dialysis sessions being complicated by IDH in the mannitol group. A larger multicenter randomized controlled trial is warranted.FundingGovernment funding to an author (Dr Mc Causland is supported by National Institute of Diabetes and Digestive and Kidney Diseases grant K23DK102511).Trial RegistrationRegistered at ClinicalTrials.gov with study number NCT01520207.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research