Association of vitamin D receptor polymorphisms and nephrolithiasis: A meta-analysis.

Association of vitamin D receptor polymorphisms and nephrolithiasis: A meta-analysis. Gene. 2019 Jun 15;: Authors: González-Castro TB, Blachman-Braun R, Hernández-Díaz Y, Tovilla-Zárate CA, Pérez-Hernández N, Moscardi PRM, Alam A, Borgonio-Cuadra VM, Reyes-López PA, Juárez-Rojop IE, López-Narváez ML, Posadas-Sánchez R, Vargas-Alarcón G, Rodríguez-Pérez JM Abstract Nephrolithiasis is a complex disease in which its pathophysiology is strongly influenced by genetics. Polymorphisms of the vitamin D receptor (VDR) gene have been reported to be associated with the development of kidney stones which in most cases are composed predominantly of calcium salts. For the purpose of this study, we performed a systematic review and meta-analysis to analyze the association of BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236) and FokI (rs2228570) polymorphisms with nephrolithiasis. A systematic search was performed up to June 2018 using PubMed, Embase and ISI Web of Knowledge databases. The keywords used for the search were "vitamin D receptor or VDR" and "polymorphisms or SNPs" combined with "urolithiasis or nephrolithiasis". A meta-analysis was performed with the results of the selected and included studies. After analyzing 23 publications, we observed that BsmI polymorphism (rs1544410) has a protective association against nephrolithiasis (Allelic model: OR = 0.84, CI 95% 0.73-0.96, Z p-value 0.015; homozygous model: OR = 0....
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research