Cancers, Vol. 11, Pages 845: Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types

Cancers, Vol. 11, Pages 845: Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types Cancers doi: 10.3390/cancers11060845 Authors: Monique K. van der Kooij Frank M. Speetjens Sjoerd H. van der Burg Ellen Kapiteijn Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic origin and display the same cellular function. Despite their common origin, both CM and UM display extreme differences in their genetic alterations and biological behavior. We discuss the differences in genetic alterations, metastatic routes, tumor biology, and tumor-host interactions in the context of their clinical responses to targeted- and immunotherapy.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research