Suicide Is a Confounder in Postmortem Studies on Depression

Over the past decade, pioneering studies have reported changes in various genes and proteins in postmortem brain  samples of major depressive disorder (MDD) patients [e.g., (1–14); see also (15–17)] (Table 1). Even though clear inferences were made based on these results regarding underlying disease mechanisms, the results differ clearly between different studies, often even in opposite directions, and e ven if the patient groups had been carefully matched for factors like age, sex, and postmortem delay.

Source: Biological Psychiatry - June 17, 2019 Category: Psychiatry Authors: Juan Zhao, Paul J. Lucassen, Dick F. Swaab Tags: Correspondence Source Type: research