Functional MRI to Study Gait Impairment in Parkinson ’s Disease: a Systematic Review and Exploratory ALE Meta-Analysis

AbstractPurpose of ReviewWhilst gait impairment is a main cause for disability in Parkinson ’s disease (PD), its neural control remains poorly understood. We performed a systematic review and meta-analysis of neuroimaging studies of surrogate features of gait in PD.FindingsAssessing the results from PET or SPECT scans after a period of actual walking as well as fMRI during mental imagery or virtual reality (VR) gait paradigms, we found a varying pattern of gait-related brain activity. Overall, a decrease in activation of the SMA during gait was found in PD compared to elderly controls. In addition, the meta-analysis showed that the most consistent gait-related activation was situated in the cerebellar locomotor region (CLR) in PD.SummaryDespite methodological heterogeneity, the combined neuroimaging studies of gait provide new insights into its neural control in PD, suggesting that CLR activation likely serves a compensatory role in locomotion.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research

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ConclusionsArmodafinil, modafinil, and methylphenidate were associated with a decreased risk of parkinsonism, as were β-agonists. Of the β-blockers, only propranolol was associated with increased risk. Healthcare database analyses that incorporate scientific rigor provide insight and direction for drug discovery efforts. These findings show association not causality; however, they offer considerable support to th e association between β-adrenergic receptor modulation and risk of Parkinson’s disease.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research
ánchez As the leading causes of human disability and mortality, neurological diseases affect millions of people worldwide and are on the rise. Although the general roles of several signaling pathways in the pathogenesis of neurodegenerative disorders have so far been identified, the exact pathophysiology of neuronal disorders and their effective treatments have not yet been precisely elucidated. This requires multi-target treatments, which should simultaneously attenuate neuronal inflammation, oxidative stress, and apoptosis. In this regard, astaxanthin (AST) has gained growing interest as a multi-target pharmac...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
EL Abstract Background: Exercise shows promise for improving physical and cognitive functioning, quality of life, and mood in individuals with Parkinson's disease (PD). Structured interviews have suggested potential factors influencing participation in exercise in this population, but no studies have examined if they predict exercise behaviour. Methods: Thirty persons with PD completed the International Physical Activity Questionnaire and a semi-structured interview. Time spent exercising was calculated by summing responses for recreation, sport, and leisure-time physical activity. Predictors of exercise were ass...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
In conclusion, we show here that sEVs are responsible for mediating paracrine senescence and speculate that they could be involved in inducing bystander senescence during therapy-induced senescence or aging. In fact, when compared to soluble factors, sEVs have different biophysical and biochemical properties as they have a longer lifespan than do soluble factors and they are more resistant to protease degradation. The idea that blocking sEV secretion could be a potential therapeutic approach to alleviate senescence "spreading" during chemotherapy-induced senescence or in aging tissues presents itself as a very at...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Dual-task interference (DTI) leads to impairment of hand dexterity in Parkinson's disease (PD). The performance of activities of daily living (ADL) is negatively affected by dexterity in PD. However, the contribution of DTI to dexterity-related ADL disability remains unclear. This cross-sectional study aimed to investigate the contribution of DTI to ADL performance as well as other factors affecting dexterity.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
MONDAY, July 8, 2019 -- For male patients with Parkinson disease, sexual activity is associated with lower motor and nonmotor disability, according to a study published online July 3 in the European Journal of Neurology. Marina Picillo, M.D., from...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
(Wiley) New research published in the European Journal of Neurology indicates that an active sexual life is linked with lower disability and better quality of life in men with early Parkinson's disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 29 June 2019Source: Neuroscience LettersAuthor(s): Camila Medeiros Costa, Gabriella Luciana de Oliveira, Angélica Cristina Sousa Fonseca, Raquel de Carvalho Lana, Janaíne Cunha Polese, Andrei Pereira PernambucoAbstractThe aim of this study was to evaluate salivary cortisol and plasma brain-derived neurotrophic factor (BDNF) in people with PD, to compare them with healthy controls and to associate them with levels of anxiety and depression. For this, 18 people with PD and 17 controls were recruited. The stage of the disease was determined by Hoehn and Yahr Disability Scale (H...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 27 June 2019Source: International Review of NeurobiologyAuthor(s): Margaret K.Y. Mak, Irene S.K. Wong-YuAbstractParkinson's disease is the second most common neurodegenerative disease with a prevalence rate of 1–2 per 1000 of the population worldwide. Pharmacological management is the mainstay of treatment. Despite optimal medication, motor impairment particularly balance and gait impairment persist leading to various degree of disability and reduced quality-of-life. The present review describes motor impairment including postural impairment, gait dysfunction, reduced muscle strengt...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
This study employed a registry of disability evaluation and functional assessment using the Taiwan Data Bank of Persons with Disability between July 2012 and October 2018. To investigate dementia-related disability in PwP, 1:1 matching by age and Hoehn-Yahr stage was conducted, which resulted in the inclusion of 1605 study participants in each group. The present study demonstrated that among the six major domains of WHODAS 2.0, the section of “Getting alone with others” was significantly worse in both genders of PwP with dementia; however, a greater disability in fulfilling activities of daily living wa...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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