Canada's largest national dementia research initiative funded for second phase by the CIHR

(Baycrest Centre for Geriatric Care) Thanks to a $46-million investment from the Canadian Institutes of Health Research (CIHR) and other funding partners, the Canadian Consortium on Neurodegeneration in Aging (CCNA) will be renewed for a second phase, as announced by the Minister of Health, the Honourable Ginette Petitpas Taylor, today.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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AbstractFrontotemporal dementia (FTD) is a highly heritable group of neurodegenerative disorders, with around 30% of patients having a strong family history. The majority of that heritability is accounted for by autosomal dominant mutations in the chromosome 9 open reading frame 72 (C9orf72), progranulin (GRN), and microtubule-associated protein tau (MAPT) genes, with mutations more rarely seen in a number of other genes. This review will discuss the recent updates in the field of genetic FTD. Age at symptom onset in genetic FTD is variable with recently identified genetic modifiers includingTMEM106B (inGRN carriers partic...
Source: Journal of Neurology - Category: Neurology Source Type: research
CONCLUSIONS: Our findings imply a shared underlying pathology relating MS and brain volume and suggest cognitive functional declines through the muscle-brain axis. Further longitudinal studies are needed to find possible and related causes of reduced MS and cortical atrophy in patients with dementia. PMID: 31311027 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
CONCLUSIONS: The ACE-R s is sensitive, specific and reliable to detect dementia in persons aged ≥50 years in a Sinhala-speaking population and its diagnostic accuracy is superior to previously validated tools (MMSE and MoCA). PMID: 31311022 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
CONCLUSION: Our findings concur with previous research advocating that MCI is a heterogeneous concept, since the prevalence and incidence estimates differed substantially according to age, MCI subtype, and severity of cognitive impairment. PMID: 31311017 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
CONCLUSIONS: Reduction in Αβ42 in DLB may be more common (>80% of patients) than previously thought, and ∼40% may have the typical CSF AD biomarker profile. AD biochemistry in DLB may be an evolving process showing increasing frequency with disease progression. PMID: 31311013 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Providing care for someone who lives with any type of dementia — whether it’s Alzheimer’s, vascular, Lewy body or any of the myriad incarnations — can be intimidating. We watch helplessly as someone we love changes dramatically in how they view the world, and in the words and actions that they can understand. These changes can lead to situations where we unintentionally say and do things that make life harder for everyone involved. Read more about what not to say if you are a caregiver for someone who lives with dementia: Carol Bradley Bursack is the Candid Caregiver MedicareFAQ – Medicare Res...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Publication date: Available online 16 July 2019Source: NeuroImage: ClinicalAuthor(s): Alexa Haeger, Ana S. Costa, Jörg B. Schulz, Kathrin ReetzAbstractCurrent treatment in late-life cognitive impairment and dementia is still limited, and there is no cure for brain tissue degeneration or reversal of cognitive decline. Physical activity represents a promising non-pharmacological interventional approach in many diseases causing cognitive impairment, but its effect on brain integrity is still largely unknown. Especially research of cerebral alterations in disease state that goes beyond observations of clinical improvement...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
The female brain is more efficient then the male brain in the early stages of dementia, which may explain the female advantage when it comes to maintaining verbal memory.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Neurology & Neurosurgery News Source Type: news
Publication date: Available online 16 July 2019Source: Journal of Aging StudiesAuthor(s): Annette LeibingAbstractBased on fieldwork in a specialized geriatric outpatient clinic in Brazil, this article shows how a humanistic discourse that ‘means well’ can do good, but can also produce a regime of care that ultimately results in care that is contrary to stated values. These values – such as holistic care, multidisciplinarity, and empathy - that have been at the heart of geriatrics since its more official founding in the 1940s and 1950s, cannot be conceived as only local. The Brazilian data mirrors internat...
Source: Journal of Aging Studies - Category: Geriatrics Source Type: research
I just blogged about a new lawsuit against Montefiore Hospital for failing to follow the patient's end-of-life directives. Now, a family member writes that another NY healthcare facility, Parker Jewish Institute for Health Care and Rehabilitation, refuses to follow her father's end-of-life wishes. Jennifer Friedlin writes: "For the past month, my mother and I have been advocating for the deactivation of my father’s pacemaker. Yet despite my parents having taken every measure to ensure that they would control the ends of their lives, two months since a severe stroke destroyed whatever qua...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
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