Identifying brain tumors by differential mobility spectrometry analysis of diathermy smoke.

CONCLUSIONS: The authors' results show that surgical smoke from various brain tumors has distinct DMS profiles and the DMS analyzer connected to a special sampling system can differentiate between tumorous and nontumorous tissue and also between different tumor types ex vivo. PMID: 31200382 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research

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Publication date: Available online 14 September 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Alexandra A.P. Mansur, Anderson J. Caires, Sandhra M. Carvalho, Nadia S.V. Capanema, Isadora C. Carvalho, Herman S. MansurAbstractGlioblastoma (GBM) is the utmost aggressive and lethal primary brain cancer, which has a poor prognosis and remains virtually incurable. Nanomedicine with emerging disruptive nanotechnology alternatives, including designed supramolecular nanohybrids has excellent potential as multimodal tools against cancer by combining nanomaterials, biomacromolecules, and drugs. Thus, we developed and c...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Authors: Ozaki T, Kinoshita M, Arita H, Kagawa N, Fujimoto Y, Kanemura Y, Sakai M, Watanabe Y, Nakanishi K, Shimosegawa E, Hatazawa J, Kishima H Abstract Brain Tumor Image Analysis (BraTumIA) is a fully automated segmentation tool dedicated to detecting brain tumors imaged by magnetic resonance imaging (MRI). BraTumIA has recently been applied to several clinical investigations; however, the validity of this novel method has not yet been fully examined. The present study was conducted to validate the quality of tumor segmentation with BraTumIA in comparison with results from 11C-methionine positron emission tomogra...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Dong Q, Li Q, Wang M, Hu J, Dai J, Niu L, Yuan G, Pan Y Abstract CD44 is involved in malignant processes including cell motility, tumor growth and angiogenesis. To explore the potential role of CD44 as a prognostic biomarker in low grade gliomas (LGG), the mRNA expression levels of CD44 in tissues from 12 patients with glioma were evaluated by microarray analysis. The mRNA level of CD44 in LGG and glioblastoma multiforme (GBM) were analyzed using datasets downloaded from the publicly available Oncomine database. Reverse transcription-quantitative PCR and western blotting were used to further analyze the CD...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: December 2019Source: Phytochemistry Letters, Volume 34Author(s): Li-Qiu Quan, Huan Liu, Rong-Tao Li, Hong-Mei LiAbstractThree new 3,8-epoxy iridoids, jatamanins V–X (1-3), and three known ones (4-6), were obtained from the roots and rhizomes of Valeriana jatamansi. The structures of 1-3 were determined through their NMR and high-resolution mass spectroscopic analysis. Among them, compounds 1 and 2 were a pair of C-4 diastereomers. Additionally, all compounds were evaluated for their cytotoxic effects against glioma stem cells.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
AbstractBackgroundThe Aphasia Rapid Test (ART) is a screening questionnaire used for examining language in acute stroke patients. The ART was initially developed and validated in French. The purpose of this study was to assess the inter-rater reliability of Italian ART.MethodsThe original version of the ART was translated into Italian. The inter-rater reliability was assessed by two independent neurologists who were blind to each other ’s ratings in 52 acute post-stroke patients.ResultsThe 52 patients (28 men, 24 women; mean age 73.73  ± 28.99 years) were included within 1 week of strok...
Source: Neurological Sciences - Category: Neurology Source Type: research
Publication date: October 2019Source: Biomedicine &Pharmacotherapy, Volume 118Author(s): Zhong-Yan Zhou, Wai-Rong Zhao, Jing Zhang, Xin-Lin Chen, Jing-Yi TangAbstractSodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA) which is an active lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza Bge. (Danshen). STS presents multiple pharmacological activities, including anti-oxidant, anti-inflammation and anti-apoptosis, and has been approved for treatment of cardiovascular diseases by China State Food and Drug Administration (CFDA). In this review, we comprehensively s...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: September 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 9Author(s): Cai-Feng DING, Zhi DAI, Hao-Fei YU, Xu-Dong ZHAO, Xiao-Dong LUOAbstractSeven new isoquinoline alkaloids, 9-(2′-formyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy dehydroaporphine (1), 9-(2′-formyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy oxoaporphine (2), 3-methoxy-2′-formyl oxohernandalin (3), (−)-9-(2′-methoxycarbonyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (4), (−)-2′-methoxycarbonyl thaliadin (5), (&min...
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
This study aims to analyze the incidence and short-term outcomes associated with stroke (ischemic and hemorrhagic) after implantation of LVAD.MethodsStudy cohorts were identified from the National Inpatient Sample database from January 2009 to September 2015 using ICD 9 codes. The primary outcome was an incidence of stroke and secondary outcomes were associated mortality, length of stay and cost of hospitalization. Multivariate logistic regression analysis was performed to analyze adjusted in-hospital mortality.ResultsUse of LVAD increased significantly from 2009 to 2014 (2,278 in 2009 to 3,730 in 2014 (Ptrend
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Conclusion In patients with newly diagnosed glioma, a combination of MRI and 18F-FLT-PET detects additional tumoral tissue and this may lead to a more complete surgical resection. Also, the addition of a negative PET to a negative MRI increases the negative predictive value. However, 18F-FLT still underestimated the margins of the lesion and did not correlate with histopathological features.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Lab study shows that drugs like paclitaxel are more effective against glioblastoma cells with higher levels of tubulin
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
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