The effect of simvastatin on warfarin anticoagulation: a Swedish register-based nationwide cohort study

ConclusionsIn conclusion, initiation of simvastatin resulted in moderately increased INR values and subsequent dose decreases in patients already on warfarin. In order to avoid the increased risk of bleeding, the initiation of simvastatin may be accompanied by closer INR monitoring.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research