Synergistic effects of geldanamycin with fluconazole are associated with reactive oxygen species in Candida tropicalis resistant to azoles and amphotericin B.

This study indicated that the oxidative stress mediated by fluconazole plus GdA played an important role in the antifungal activity, and targeting oxidative stress might extend target choices to treat fungal infections. PMID: 31185751 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31185751?dopt=Abstract

Source: Free Radical Research - June 14, 2019 Category: Research Tags: Free Radic Res Source Type: research