Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16

In conclusion, lycopene upregulates ZO-1 expression and downregulates claudin-1 expression through the activation of ERK, JNK and MTORC1 as well as the inhibition of autophagy in human cSCC cells. Our findings demonstrate that autophagy plays a key role in lycopene-mediated pharmacological effects. This study indicates that lycopene might be a useful chemopreventive agent against cSCC.

Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Suyun Bi, Li Li, Heng Gu, Min Li, Song Xu, Wenbo Bu, Mengli Zhang, Zhihai Zhou, Xu Chen Tags: Research Paper Source Type: research