High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma

In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials.

Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Michal Tich ý , Lucia Knopfov á , Ji ř í Jarkovsk ý , Petr Vl č ek, Jana Katolick á , Ivan Č apov, Mark é ta Hermanov á , Jan Š marda, Petr Bene š Tags: Short Research Communication Source Type: research