Development of ciprofloxacin and nano-hydroxyapatite dual -loaded polyurethane scaffolds for simultaneous treatment of bone defects and osteomyelitis

In this study, multifunctional bone scaffolds composed of polyurethane (PU) scaffold loaded with nano-hydroxyapatite (n-HA) and ciprofloxacin hydrochloride (CF) were fabricated. The composite scaffolds could release CF sustainably for at least 2 weeks and exhibited excellent antibacterial activity. The n-HA component in the scaffolds effectively promoted the proliferation and osteogenic differentiation of rat-bone-marrow-derived mesenchymal stem cells (BMSCs). Therefore, the prepared HA/PU-CF composite scaffolds are a functional candidate as space maintainer for the treatment of osteomyelitis
Source: Materials Letters - Category: Materials Science Source Type: research