Comparison of IL-2 vs IL-7/IL-15 for the generation of NY-ESO-1-specific T cells

In conclusion, IL-7/IL-15 does not seem to be superior to IL-2 for the generation of NY-ESO-1-specific T cells. This is in sharp contrast to the observations in CD19-specific CART cells. Changes of cytokine cocktails should be carefully evaluated for individual vector systems.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research