Fecal microbiota transplantation as a new therapy: from Clostridioides difficile infection to inflammatory bowel disease, irritable bowel syndrome, and colon cancer.

Fecal microbiota transplantation as a new therapy: from Clostridioides difficile infection to inflammatory bowel disease, irritable bowel syndrome, and colon cancer. Curr Opin Pharmacol. 2019 Jun 04;49:43-51 Authors: Borody TJ, Eslick GD, Clancy RL Abstract Fecal microbiota transplantation (FMT) represents the most effective means of therapeutically manipulating the gastrointestinal microbiome. Originally employed as a treatment of last-resort in patients with life-threatening Clostridioides difficile infection (CDI), FMT gained widespread acceptance during the CDI epidemic, where it achieved resolution rates approaching 100%. Following our newfound appreciation for the role of the gut microbiome in both health and disease and owing to FMT's unique mechanism/s of action, FMT is rapidly advancing as an effective treatment for a number of conditions in which the gastrointestinal microbiome is thought to play a role. We review the role of FMT from its beginnings in CDI to its expansion into inflammatory bowel disease, irritable bowel syndrome, and colon cancer. PMID: 31173991 [PubMed - as supplied by publisher]
Source: Current Opinion in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Opin Pharmacol Source Type: research

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Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Publication date: Available online 15 September 2019Source: Advances in Biological RegulationAuthor(s): Yi Cai, Andrew Yousef, Jennifer R. Grandis, Daniel E. JohnsonAbstractEpidemiologic evidence indicates that regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) provides a protective effect against the development of colorectal, breast, and head and neck cancers. Genomic characterization of these cancers has lent considerable insight into the subpopulations of cancer patients who are most likely to benefit from NSAID therapy. The PIK3CA gene encodes the catalytic subunit of phosphatidylinositol 3-kinase (PI3K) and...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
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Source: Advances in Biological Regulation - Category: Biology Source Type: research
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Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
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Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
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