Eicosanoid profiling in effluent of isolated perfused heart of Tg αq*44 mice with advanced heart failure.

In conclusion, eicosanoid profiling in isolated perfused heart pointed to PGI2, PGD2 and 12-HETE as the most abundant AA metabolites of the isolated murine heart. In Tgαq*44 mice, the end-stage phase of heart failure was accompanied by major activation of cyclooxygenase pathways (PGI2, TXA2, PGD2, PGE2, PGF2α), 8,9-, 11,12-EET/DHETs pathways and 12-, 15-HETEs pathways in the heart.
PMID: 31172972 [PubMed - in process]

Source: Journal of Physiology and Pharmacology - June 8, 2019 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research