Effect of Spironolactone for One Year on Endothelial Function and Vascular Inflammation Biomarkers in Renal Transplant Recipients.

CONCLUSIONS: MR blockade did not improve biomarkers of endothelial dysfunction or vascular inflammation in renal transplant patients. Since no beneficial effect of MR blockade on vascular biomarkers was found, aldosterone is likely not a major promoter of vascular dysfunction in renal transplant patients.
PMID: 31166706 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Renal Physiology - June 4, 2019 Category: Physiology Authors: Mortensen LA, Bistrup C, Stubbe J, Carlström M, Checa A, Wheelock CE, Palarasah Y, Bladbjerg EM, Thiesson HC, Jensen BL Tags: Am J Physiol Renal Physiol Source Type: research