Effects of amino acid co-infusion on increased catecholamine symptoms in metastatic pheochromocytoma patients treated with 177Lu-DOTATATE

Conclusions: Preliminary analysis suggests that there is an increase in HR and SBP after 60 minutes of PHE/TYR-containing amino acid administration which, in patients with PHEO/PGL, may represent increased sympathetic effects from temporarily boosted catecholamine biosynthesis. This is supported by the finding that increased HR and SPB is seen primarily in catecholamine secretors when using Clinisol but not with the 2.5% Lys/Arg solution. Other factors which may have contributed such as anxiety and nausea cannot be ruled out, although subgroup analysis suggests that these others factors alone does not account for the observed findings.Summary of Heart Rate (HR) and Systolic BP changes in catecholamine secretors v. non-secretorsClinisol 15%2.5% Lys/ArgHR ChangesSBP ChangesHR ChangesSBP ChangesAll+3.5+9.6All-2.2+1.5Secretors+3.5+14.8Secretors-6.0+4.5Non-Secretors+.35-0.3Non-Secretors-0.30

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Lin, F., Carrasquillo, J., Jha, A., Gonzales, M., del Rivero, J., Forest, A., Eclarinal, P., Lindenberg, M. L., Mena, E., Millo, C., Chen, C., Choyke, P., Pacak, K. Tags: Center for Therapy Excellence YIA Symposium Source Type: research