Application of probe electrospray ionization-tandem mass spectrometry to ultra-rapid determination of glufosinate and glyphosate in human serum

In this study, we addressed this limiting factor by developing an ultra-rapid and simple analytical technique using a combination of probe electrospray ionization (PESI) and tandem mass spectrometry (MS/MS), which gives quantitative results within 0.3 min. Herbicide standards were added to human serum that was then subjected to analysis (N = 5 per concentration). The analysis was repeated daily over eight consecutive days. The limit of detection (LOD) was 0.59 μg/mL for glufosinate and 0.20 μg/mL for glyphosate. The limit of quantitation (LOQ), i.e., the lowest point on the calibration curves, was 1.56 μg/mL for both the herbicides. The matrix effects were observed at three different concentrations (between 95.7%–104% for glufosinate, and between 90.7%–95.7% for glyphosate). When applied to samples taken from actual poisoning cases (six samples for each herbicide), the present method gave almost the same quantitative values as those obtained by conventional high-performance liquid chromatography with fluorescence detection. Thus, we believe that PESI-MS/MS could emerge as a rapid diagnosis method in the clinical emergency field.
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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Conclusions: Poisoning was predominant in unmarried young males from lower economic class. The most common type of poisoning was suicidal, route was oral and agent was chemicals. Vomiting and pain in abdomen were the most common clinical features. Chemical poisoning was highly associated with renal failure and aspiration chemical pneumonitis requiring ventilator support and high mortality. Chemical agent of poisoning, Intravenous route of poisoning, requirement of mechanical ventilation, duration of hospital stay were significantly associated with mortality. PMID: 31311221 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Yaylacı F, Küçük Ö, Erkuran HÖ Abstract Paliperidone is a relatively novel atypical antipsychotic drug that is currently used to treat schizophrenia in adolescents and adults. The drug was generated by combining the active metabolite of risperidone, 9-hydroxyrisperidone, with osmotic controlled-release oral administration system (OROS) technology. Due to its specific design, the drug has been identified as a different form, albeit an active metabolite of risperidone. Such distinction mainly manifests itself during pharmacokinetic processes, because paliperidone is not affected b...
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
INTRODUCTION: Suicide is a major public health challenge in Kerala. Majority of adult poisoning is intentional. Most of those who attempt 'deliberate self harm' are young adults and many a time the reason is trivial. OBJECTIVES: To find out the pat...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Conclusion: The common poisons ingested are organophosphorous compounds, drugs and odollam. Organophosphorous and odollam carries higher mortality. Pesticide regulation, use of less toxic pesticides in agriculture, early management and quick referral to well equipped hospitals will help in reducing mortality. Suicide prevention programmes like psychosocial support and counselling, raising public awareness about deliberate self harm and alcohol de-addiction programmes will help in reducing the incidence of deliberate self harm. PMID: 31304709 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
CONCLUSION: Lacosamide exposures infrequently cause death or disability; however, a considerable proportion of the study population required intensive care. Exposed patients with symptoms require healthcare evaluation. PMID: 31286429 [PubMed - as supplied by publisher]
Source: Journal of Medical Toxicology - Category: Toxicology Authors: Tags: J Med Toxicol Source Type: research
Conclusions: PSYCOHORTS lays the foundation for complex examinations of psychiatric disorders that is based on compatible datasets, use of biobanks and multigenerational approach to risk factors, and extensive data on marginalization and inequality. PMID: 31271336 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Carbon monoxide (CO) remains an insidious and silent killer due to its physical and chemical properties; its lethal effects are encountered in cases of household accidents, occupational hazards or suicide. Deaths due to CO poisoning were studied retrospect...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
ConclusionIn order to avoid childhood poisonings that may have such widespread and serious consequences, such products should be sold with locked covers and kept in places where children cannot reach them.
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
Authors: Mureşan CO, Zăvoi RE, Dumache RO, Precup CV, Ciocan V, Bulzan OŞ, Florou C, Enache A Abstract Carbon monoxide (CO) remains an insidious and silent killer due to its physical and chemical properties; its lethal effects are encountered in cases of household accidents, occupational hazards or suicide. Deaths due to CO poisoning were studied retrospectively in the period 2000-2018 at the Institute of Forensic Medicine, Timişoara, Romania. These cases represent 1.75% of all the autopsies and 0.63% of all violent deaths. There have been cases of single deaths and cases with multiple victims - concomitant dea...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
We report a new type of stimulus-bound behavior, denoted forced person-following, which we documented for a patient with hypoxic encephalopathy following a suicide attempt with carbon monoxide poisoning. The patient's brain was damaged in the bilateral frontal, parietal, and temporal lobes and in the basal ganglia. The patient was compelled to follow any person who came into his sight and would continue to do so until the person went out of his sight. The patient also exhibited certain primitive reflexes. The forced person-following exhibited by our patient appears to be a consequence of stimulus-bound behavior due to fron...
Source: Neurocase - Category: Neurology Authors: Tags: Neurocase Source Type: research
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