Hypericin enhances β-lactam antibiotics activity by inhibiting sarA expression in methicillin-resistant Staphylococcus aureus

In this study, the authors demonstrated that hypericin, as a sarA inhibitor, had synergistic activity with β-lactams both in vitro and in a murine bacteremia model due to MRSA. The mechanisms may be related to significantly reduced biofilm formation, fibronectin binding and expression of virulence genes (e.g., fnbA and hla)
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research