Single ‐dose diclofenac in healthy volunteers can cause decrease in renal perfusion measured by functional magnetic resonance imaging

ConclusionsSingle ‐dose diclofenac caused a decrease in renal perfusion in participants with diclofenac levels ≥225 nm. We demonstrated that even a single dose of diclofenac can impair renal perfusion, which could be detrimental in patients with underlying chronic kidney disease or acute kidney injury.

Source: Journal of Pharmacy and Pharmacology - May 26, 2019 Category: Drugs & Pharmacology Authors: Susanne Hellms, Faikah Gueler, Marcel Gutberlet, Nils Helge Schebb, Katharina Rund, Jan T. Kielstein, VanDai VoChieu, Sebastian Rauhut, Robert Greite, Petros Martirosian, Hermann Haller, Frank Wacker, Katja Derlin Tags: Research Paper Source Type: research