Correlation Network Analysis Shows Divergent Effects of a Long-Term, High-Fat Diet and Exercise on Early-Stage Osteoarthritis Phenotypes in Mice

ConclusionDespite minimal group-level effects of chronic diet-induced obesity and voluntary wheel running on knee OA pathology under the current test durations, diet and exercise substantially altered the relationships among systemic and local variables associated with early-stage knee OA. These results suggest that distinct pre-OA phenotypes may exist prior to the development of disease.Graphical Abstract
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research