Decolonization Reduces Risk of Postdischarge MRSA

According to this study: Decolonization with chlorhexidine and mupirocin led to lower risks of postdischarge methicillin-resistant Staphylococcus aureus and readmission compared with hygiene education alone.
Source: AJN - Category: Nursing Tags: Journal Watch Source Type: research

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In this study, we evaluated the antimicrobial activity of the extracts from herbal plant Persicaria pensylvanica’s flower, leaf, stem, and root. This plant is also known by a common name Pennsylvania smartweed. The antimicrobial effect of the extracts was tested using minimum inhibitory concentration (MIC) and minimum bacteriocidal concentration (MBC) methods in comparison with tetracycline, a commercial antibiotic.ResultsWe found that extract from P. pensylvanica kills bovine mammary glands pathogenic S. aureus strain Newbould 305. The minimum inhibitory concentration (MIC) breakpoints for extracts from the flower, ...
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
E-101 solution is a first-in-class myeloperoxidase-mediated antimicrobial developed for topical application. It is composed of porcine myeloperoxidase (pMPO), glucose oxidase (GO), glucose, sodium chloride, and specific amino acids in an aqueous solution. Once activated, the reactive species hydrogen peroxide (H2O2), hypochlorous acid, and singlet oxygen are generated. We evaluated the treatment effects of E-101 solution and its oxidative products on ultrastructure changes and microbicidal activity against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Time-kill and transmission electron microscop...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Bacterial Infections Source Type: research
Publication date: 1 September 2019Source: Journal of Molecular Liquids, Volume 289Author(s): Aurora Pinazo, Ramon Pons, Marta Bustelo, María Ángeles Manresa, Carmen Morán, Miriam Raluy, Lourdes PérezAbstractNew gemini cationic surfactants bearing imidazolium groups as polar heads and alkyl chains of various lengths were prepared using the amino acid histidine as starting material. These surfactants were found to have very low cmc values and reduced the surface tension of water solutions with high efficiency.Their biological properties, antimicrobial and hemolytic activities, depended on the alky...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
ConclusionLME in combination with clotrimazole exhibited synergy effect against C. albicans and T. rubrum. In combination with artocarpin, it showed synergy effect against MRSA.
Source: Chinese Herbal Medicines - Category: Complementary Medicine Source Type: research
The toxic shock syndrome toxin-1 (TSST-1), encoded by tst gene, has been proposed to cause staphylococcal toxic shock syndrome (TSS) in a susceptible host, which highlights the need to evaluate the level of tst gene expression and molecular genetic characteristics of the tst-positive isolates. A total of 916 S. aureus isolates collected from seven hospitals in China were screened for the tst gene. The tst positive isolates were characterized by spa, SCCmec, PFGE and agr typing. Representative strains were also subjected to MLST typing. qRT-PCR was used to quantify tst and major virulence regulator genes expression. We also...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSIONS: DM patients with poor glucose control are more susceptible to MRSA infection. They suffer from higher antimicrobial resistance, a higher co-infection rate, and much severer pneumonia than non-DM. MRSA itself is an independent risk factor for mortality in all patients. PMID: 31205100 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Publication date: Available online 17 June 2019Source: Veterinary MicrobiologyAuthor(s): Igor Loncaric, Sarah Lepuschitz, Werner Ruppitsch, Alan Trstan, Thomas Andreadis, Nikolaos Bouchlis, Helene Marbach, Bernhard Schauer, Michael P. Szostak, Andrea T. Feßler, Frank Künzel, Theresia Licka, Burkhard Springer, Franz Allerberger, Stefan Monecke, Ralf Ehricht, Stefan Schwarz, Joachim SpergserAbstractThe aim of the present study was to investigate the diversity of methicillin-resistant Staphylococcus aureus (MRSA) that originated from Austrian companion animals during the last five-year period. A total of 90 non-rep...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In this study, we examined the difference in bacterial colonization of different curtains. We experimentally contaminated antibacterial Fantex protective curtains and compared the bacterial counts to natural contamination of privacy curtains. There was a significant reduction in the CFU/cm2 on antibacterial Fantex protective privacy curtains after 24 hours of experimental contamination with Pseudomonas aeruginosa, Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus (MRSA) or extended-spectrum-producing organisms (Escherichia coli or Klebsiella pneumoniae), compared to standard privacy curtains. Levels of e...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
In this study, we investigated the effects of short-chain fatty acids, metabolites produced by commensal bacteria, on the growth of S. aureus both in vitro and in vivo. Sodium propionate (NaP) most potently inhibited the growth of MRSA and multidrug-resistant clinical isolates. Of note, only NaP, but not NaA or NaB, ameliorated MRSA skin infection, significantly lowering bacterial load, excessive cytokine production, and the size and weight of abscesses approximately by two-fold. In addition, interestingly, S. aureus deficient of lipoteichoic acids (LTA) or wall teichoic acids (WTA), which are important in bacterial physio...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionA significant proportion of patients acquiredS. aureus during hospitalization. The finding of more than 90% ofS. aureus SSI to be of endogenous source underscores the need of improving infection prevention and control measures including screening and decolonization of high risk patients.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
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