Nanomaterial–based electrochemical (bio)-sensing: one step ahead in diagnostic and monitoring of metabolic rare diseases

Publication date: Available online 22 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Laura García-Carmona, María Cristina González, Alberto EscarpaAbstractMetabolic rare diseases present a serious clinical manifestation causing several problems such as mental retardation, liver damage, hepatocarcinoma and even death without a diagnosis in the first days of life. Additionally, there is not any final treatment for these diseases but a dietary restriction, so patients have to control their biomarkers level during their whole life. Current methods for diagnosis and monitoring are tedious, very time-consuming, not portable and need high amount of sample, so they are not suitable for a point-of-care (POC) application. In this sense, electrochemistry presents the required characteristics to be used as POC for metabolic rare diseases. Specifically, this review explores the current methods for amino acids and carbohydrates sensing as biomarkers of metabolic rare diseases using electrochemical (bio)-sensing approaches, especially those based on nanomaterials in both, off and on-chip detection, as well as their suitability in metabolic rare diseases diagnosis and monitoring using clinical samples.
Source: TrAC Trends in Analytical Chemistry - Category: Chemistry Source Type: research