Synthetic developmental biology: build and control multicellular systems.

Synthetic developmental biology: build and control multicellular systems.
Curr Opin Chem Biol. 2019 May 15;52:9-15
Authors: Ebrahimkhani MR, Ebisuya M
Abstract
Synthetic biology offers a bottom-up engineering approach that intends to understand complex systems via design-build-test cycles. Embryonic development comprises complex processes that originate at the level of gene regulatory networks in a cell and emerge into collective cellular behaviors with multicellular forms and functions. Here, we review synthetic biology approaches to development that involve building de novo developmental trajectories or engineering control in stem cell-derived multicellular systems. The field of synthetic developmental biology is rapidly growing with the help of recent advances in artificial gene circuits, self-organizing organoids, and controllable tissue microenvironments. The outcome will be a blueprint to decode principles of morphogenesis and to create programmable organoids with novel designs or improved functions.
PMID: 31102790 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - May 14, 2019 Category: Biochemistry Authors: Ebrahimkhani MR, Ebisuya M Tags: Curr Opin Chem Biol Source Type: research