Intratympanically Delivered Steroids Impact Thousands More Inner Ear Genes Than Systemic Delivery.

CONCLUSIONS: Thousands of inner ear genes were affected by steroids, and this number increased significantly if steroids were delivered intratympanically. Also, the impact of glucocorticoids on inner ear mineralocorticoid functions is more substantial than previously known. Thus, the application of therapeutic steroids for hearing loss needs to be reassessed in light of their more comprehensive impact on inner ear genes. Furthermore, simply ascribing the efficacy of steroids to immunosuppression no longer appears to be warranted. PMID: 31092042 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31092042?dopt=Abstract

Source: The Annals of Otology, Rhinology, and Laryngology - May 18, 2019 Category: ENT & OMF Authors: Trune DR, Shives KD, Hausman F, Kempton JB, MacArthur CJ, Choi D Tags: Ann Otol Rhinol Laryngol Source Type: research