Risk modeling the mortality impact of antimicrobial resistance in secondary pneumococcal pneumonia infections during the 2009 influenza pandemic

Antimicrobial resistance (AMR) is an important factor for consideration in pandemic preparedness. Any reduction in treatability poses a potential risk to national and international security and economic stability when applied to pandemic-related pathogens (McArthur and Tsang, 2017). Increasing AMR among pathogens responsible for the development of community-acquired pneumonia (CAP) (e.g. Streptococcus pneumoniae and Haemophilus influenzae) (Adam, 2002) is especially concerning given their propensity to cause bacterial infections secondary to viral influenza.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research

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Authors: Brignardello-Petersen R PMID: 31606117 [PubMed - as supplied by publisher]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
ConclusionsThe overall VTE rate after CABG has been low. However, the condition has been associated with worse 30-day postoperative outcomes and complications. The independent predictors of VTE development included a history of bleeding disorders, congestive heart failure in the 30 days before surgery, and operative time of ≥310 minutes. Understanding these risk factors should aid physicians in the decisions regarding prophylaxis and treatment.
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
By KIP SULLIVAN, JD The Medicare Payment Advisory Commission (MedPAC) and other proponents of the Hospital Readmissions Reduction Program (HRRP) justified their support for the HRRP with the claim that research had already demonstrated how hospitals could reduce readmissions for all Medicare fee-for-service patients, not just for groups of carefully selected patients. In this three-part series, I am reviewing the evidence for that claim. We saw in Part I and Part II that the research MedPAC cited in its 2007 report to Congress (the report Congress relied on in authorizing the HRRP) contained no studies supporting tha...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Policy Medicare health reform Hospital Readmissions Reduction Program HRRP Kip Sullivan MedPAC Source Type: blogs
The University of California, San Francisco (UCSF) is launching a new center...Read more on AuntMinnie.comRelated Reading: Radiofrequency ultrasound, AI predict thyroid cancer AI model could speed up pneumonia diagnosis in ED Societies team up to promote ethics in radiology AI AI algorithm can accurately diagnose appendicitis Nvidia, ACR collaborate on AI for radiology
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
ConclusionThe AMK resistance rate in M. abscessus clinical isolates in this study was low (2.6%). The A1408 G mutation in rrs and overexpression of WhiB7 and Tap were the predominant mechanisms of AMK resistance in M. abscessus.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionIn summary, our results show that farms are an important reservoir of colistin-resistant E.coli, added to other additional genes, such as blaESBL. The transfer of manure from animals to soil and irrigation water might be spreading a mix of multiple resistances, posing a worrying threat to human health.Graphical abstract
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
AbstractAntimicrobial resistance (AMR) has emerged as an obstacle in the supple administration of antimicrobial agents to critical diarrheal patients. Most diarrheal pathogens have developed resistance against the major classes of antibiotics commonly used for assuaging diarrheal symptoms. Antimicrobial resistance develops when pathogens acquire antimicrobial resistance genes (ARGs) through genetic recombination from commensals and pathogens. These are the constituents of the complex microbiota in all ecological niches. The recombination events may occur in the environment or in the gut. Containment of AMR can be achieved ...
Source: Gut Pathogens - Category: Microbiology Source Type: research
We report a case of an infected chylothorax occurring in a post-cardiac surgery patient caused bySerratia marcescens. Once considered a harmless saprophyte,Serratia marcescens is now recognized as an important opportunistic pathogen causing healthcare-associated infection with a propensity for antimicrobial resistance.
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsBronchodilator dose responsiveness may be useful for phenotyping and may be of utility in practice and future studies focused on asthma outcomes or quantification of treatment responses. In children and adolescents, this phenotype of poor bronchodilator responsiveness may be associated with periods of relatively stable disease yet marked airway constriction in response to triggers, including tobacco smoke, respiratory infections/pneumonia, and aeroallergens.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
This study aimed to assess the risk factor for mortality owing to VAP. MATERIAL AND METHODS This retrospective clinical audit study screened medical records between the period of January 2014 and December 2017. All patients under mechanical ventilation MV) for ≥72 hours were screened against previously reported diagnostic criteria for VAP. The medical records were obtained for cases of documented diagnosis of VAP. RESULTS In all, 145 patients (5.0%) diagnosed with VAP were included in the study; the morbidity of VAP was 19.5 episodes per 1000 days of MV. The 30-day mortality rate was 42.8%. Univariate logistic analysis ...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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