Patient-reported symptoms during and after direct acting antiviral therapies for chronic hepatitis C: The PROP UP Study

Patients with chronic hepatitis C virus (HCV) infection often report neuropsychiatric, somatic, and gastrointestinal symptoms including fatigue, sleep disturbance, musculoskeletal pain, depression, and abdominal pain [1 –3]. Patients may attribute these symptoms to HCV, a chronic viral infection associated with several extrahepatic disorders. Recent studies show that health-related quality of life and other patient-reported outcomes (PROs) improve during all-oral direct-acting antiviral (DAA) therapy and after pa tients achieve a sustained virological response (SVR) [4–6].

Source: Journal of Hepatology - May 12, 2019 Category: Gastroenterology Authors: Donna M. Evon, Souvik Sarkar, Jipcy Amador, Anna S. Lok, Richard K. Sterling, Paul W. Stewart, Bryce B. Reeve, Marina Serper, Nancy Reau, K. Rajender Reddy, Adrian M. Di Bisceglie, David R. Nelson, Carol E. Golin, Joseph K. Lim, Michael W. Fried Source Type: research