S99. Herpes Simplex Virus -1 Seropositivity in Treatment Resistant Bipolar Depression

Exposure to viruses, such as mumps, rubella, poliomyelitis, cytomegalovirus and herpes simplex viruses have been proposed as risk factors for the development of psychiatric disorders and may contribute to cognitive impairment. Reduced cognitive performance was correlated with HSV-1 seropositivity in patients with BD, while cognitive impairment has been associated with a pro-inflammatory state and inflammation as a possible factor in treatment resistance.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research