Association of the TNF- α-308, TNF-α-238 Gene Polymorphisms with Risk of Bone-joint and Spinal Tuberculosis: A Meta-analysis.

Association of the TNF-α-308, TNF-α-238 Gene Polymorphisms with Risk of Bone-joint and Spinal Tuberculosis: A Meta-analysis. Biosci Rep. 2019 May 09;: Authors: Huang W, Zhou R, Li J, Wang J, Xiao H Abstract The aim of this study was to investigate the association of TNF-α-308 and TNF-α-238 gene polymorphisms with the risk of bone-joint and spinal tuberculosis by meta-analysis. By searching PubMed, Web of Science, Wanfang databases, CNKI, Medline, and Cochrane Library, the published articles about studies of the association of the TNF-α-308, TNF-α-238 gene polymorphisms with risk of bone-joint and spinal tuberculosis were collected by two reviewers. Begg's tests and Egger's tests were performed to assess publication bias. Stata 12.0 software was used for data analysis. The symmetry of the funnel plot indicated no significant publication bias in the Begg's test (A: p=1.00, B: p=0.764), and the results of the Egger's test showed no evidence of publication bias (A: p=0.954, B: p=0.626). Seven studies assessed the relationship between TNF-α-308 gene polymorphisms and risk of bone-joint and spinal tuberculosis risk. The heterogeneity (I2) of GG vs. AA or AG was 0% and there was no heterogeneity (χ2=0.06, and p=0.944) in a fixed-effects model. There was also a lack of association between TNF-α-308 polymorphism and bone-joint and spinal tuberculosis risk under the recessive model. The remaining models of the TNF-α-308 genotype an...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research