MiR-200c downregulates HIF-1 α and inhibits migration of lung cancer cells.

Conclusion: miR-200c negatively affects hypoxia-induced responses by downregulating HIF-1α, a key regulator of hypoxia. Therefore, overexpression of miR-200c might have therapeutic potential as an anticancer agent that inhibits tumor hypoxia. PMID: 31061665 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31061665?dopt=Abstract

Source: Cellular and Molecular Biology Letters - May 9, 2019 Category: Biochemistry Authors: Byun Y, Choi YC, Jeong Y, Lee G, Yoon S, Jeong Y, Yoon J, Baek K Tags: Cell Mol Biol Lett Source Type: research