Establishing Peer Manding in Young Children with Autism Using a Speech-Generating Device
This study evaluated the use of theinterrupted chain procedure in the establishment of peer manding for three young children with a diagnosis of autism. The procedures involved the presentation of a task related activity (i.e., puzzle) and the neuro-typical peer interrupted the behavioral chain of task completing by withholding the final piece needed to complete the task. An iPad ® based SGD was used as an AAC for the participants to mand for the missing item needed to complete the task related activity from the peer. Additionally, a five-second-time delay with full physical prompts was used for instructional purposes. The results indicated that all three participants acqui red the ability to mand for the missing item from the peer, and this skill was also found to maintain following training.
In this study, we have used a novel DNAzyme based approach to create a larval model of FXS in zebrafish with specific focus on the early developmental window.MethodsFmr1specific DNAzymes were electroporated into embryos to create theknockdown. Changes in RNA and protein levels of FMRP and relevant biomarkers were measured in the 0-7dpf window. Behavioral tests to measure anxiety, cognitive impairments and irritability in the larvae were conducted at the 7dpf stage. Drug treatment was carried out at various time points in the 0-7dpf window to identify the critical window for pharmacological intervention.ResultsThe DNAzyme b...
We report here the derivation of familial iPSC lines from two controls and three ASD patients carrying NRXN1α+/−, using a non-integrating Sendai viral kit. The genotype and karyotype of the resulting iPSCs were validated by whole genome SNP array. All iPSC lines expressed comparable levels of pluripotency markers and could be differentiated into three germ layers.
ConclusionsPrevention efforts to reduce ED utilization, especially for those with ID and ASD with co-occurring psychiatric conditions, is warranted. Primary care providers and case managers should develop care plans to reduce the likelihood for emergency psychiatric utilization and ensure alternative care pathways. ED clinicians may require additional training to address the needs of this population when they present to the ED in crisis.
ConclusionsThese data contribute to identifying an early trend of autism spectrum disorder, useful also for pediatricians.
We describe QoL data gathered using the Pediatric Quality of Life Inventory (PedsQL) completed online by 364 parents of youth with FXS. Parents consistently reported across all gender and age groups that their children experienced the highest QoL in Physical functioning and the lowest QoL in Cognitive functioning. Overall, older children with FXS had increase QoL ratings in the domains of School and Cognitive function. PMID: 31728808 [PubMed - as supplied by publisher]
This report condemns the'horrific reality'of conditions and treatment under which many young people with learning disabilities and autism are detained in mental health hospitals,'inflicting terrible suffering on those detained and causing anguish to their distraught families'. It calls for an overhaul of inspections and changes to the Mental Health Act to protect those detained and for the establishment of a Number 10 unit with Cabinet-level leadership to urgently drive forward reform.
These frameworks describe the skills, knowledge and behaviours needed by health and social care staff, and will be used to inform the development and planning of the current and future workforce.
Abstract Asperger's Syndrome was introduced as a separate diagnostic category in the DSM-4 (1994). Its subsequent absorption into autism spectrum disorder in the DSM-5 (2013) led to vigorous debate and concerns about the loss of the unique Asperger's identity. Existing research has identified that adults previously diagnosed with Asperger's have expressed a diverse range of opinions regarding the DSM-5 changes. This Australian study explored the role of disability identity development in responses to the change through semi-structured interviews with 12 adults diagnosed with Asperger's under the DSM-4. Their diffe...
This report outlines the development process, content, and global field-testing strategy of the WHO CST program. The CST program is designed to be feasible, scalable, and adaptable and appropriate for implementation in low-resource settings by nonspecialists. The program was informed by an evidence review utilizing a common elements approach and was developed through extensive stakeholder consultation and an iterative revision process. The program is intended for a global audience and was designed to be adapted to the cultural, socioeconomic, geographic, and resource context in which it is used to ensure that it is compreh...