An update of systemic analgesics in children

Publication date: Available online 3 May 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Jennifer A. WrightAbstractEffective and safe pain management in children can be complex and challenging. It remains an important goal in order to minimize acute distress, behavioural changes, central sensitization and hyperalgesia. Neonates are particularly susceptible to long-term neurodevelopmental changes due to the neuroplasticity of their immature brains, and adequate analgesia may help ameliorate these changes. The focus of this review is to look at systemic analgesic options available for children, infants and neonates. This review includes a brief description of important pharmacokinetic, pharmacodynamic and pharmacogenomic issues that can influence the effectiveness and safety of these medications, while highlighting the impact organ-immaturity in neonates can have on pain processing and analgesic pharmacology.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research

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ConclusionThe surgeons agree with the statement that success in the preventing reankylosis after TMJ gap arthroplasty. Its primarily refers to the early postoperative physiotherapy, maintained on a long term.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 18 July 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Alan David Kaye, Mark W. Motejunas, Lauren A. Bonneval, Ken P. Ehrhardt, Dustin R. Latimer, Andrea Trescot, Kyle E. Wilson, Ibraham N. Ibrahim, Elyse M. Cornett, Richard D. Urman, Kenneth D. CandidoAbstractChronic pain management techniques have evolved in recent years. In this regard, ultrasound technology has become a standard for most acute pain procedures and essential for postsurgical pain relief and enhanced recovery after surgery protocols. This manuscript summarizes clinical studies evaluating ultra...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
Conclusion4% Articaine is more potent and has longer duration of action with better postoperative analgesia and could be considered as an alternative to lignocaine in clinical practice. With management of postoperative pain being the critical component of patient care, clinical trials are required to develop long acting local anesthetic with increased postoperative analgesia effect.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
ConclusionThere is an overwhelming lack of evidence regarding CPSP and its management for patients undergoing elective mid/hindfoot and ankle surgery. The lack of a recognized and standard definition of CPSP after this group of surgeries precludes accurate and consistent evaluation.
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
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Source: Anesthesiology Research and Practice - Category: Anesthesiology Tags: Anesthesiol Res Pract Source Type: research
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Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Conclusion: This case series was able to demonstrate that our described novel spinal cord stimulator trial lead placement and dressing technique can decrease the incidence of lead displacement and migration, thus improving trial success. PMID: 31281554 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
The objective of this study was to evaluate the reproducibility and the consistency of a visual analogue scale for anxiety compared with the reference method, the State ‐Trait Anxiety Inventory (STAI).DesignObservational, prospective, monocentric study of 500 patients in the post ‐anaesthetist care unit. Anxiety was evaluated using both the visual analogue scale for anxiety and the STAI in perioperative patients. Consistency between the visual analogue scale for anxiety and the STAI, detection thresholds and factors predicting anxiety were researched.ResultsA correlation was found between the visual analogue scale for ...
Source: Nursing Open - Category: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research
Access to internationally controlled essential medicines is a problem worldwide. More than 5 billion people cannot access opioids for pain and palliative care or do not have access to surgical care or anesthetics, 36 million people living with epilepsy do not have access to their medicines, and 120.000 women die annually due to post-partum hemorrhage. In Uganda access to controlled medicines is also problematic, but a lack of data on factors that influence access exists.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
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