Secondary fermented extract of Chaga-Cheonggukjang attenuates the effects of obesity and suppresses inflammatory response in the liver and spleen of high-fat diet-induced obese mice.

Secondary fermented extract of Chaga-Cheonggukjang attenuates the effects of obesity and suppresses inflammatory response in the liver and spleen of high-fat diet-induced obese mice. J Microbiol Biotechnol. 2019 Apr 27;: Authors: Na HG, Park Y, Kim MA, Lee JW, So G, Kim SH, Jang KH, Kim MJ, Namkoong S, Koo HJ, Lee SR, Sohn EH Abstract Cheonggukjang and Chaga mushroom have numerous health benefits, and have been used in alternative medicine. The powder mixture of 98: Cheonggukjang and 2: Chaga extracts were fermented with Lactobacillus acidophilus KCTC3925 (FCC) and its obesity effects in high fat diet (HFD)-induced obese mice were determined. Five-week-old male ICR mice were fed a normal diet or HFD in the presence or absence of 3% and 5% FCC (FCC3 and FCC5) by weight (n = 10 per group). After 12 weeks, the mice were sacrificed, and serum and tissue samples were examined. Body weight and epididymal fat pad weight were significantly lowered in the 3% and 5% FCC groups compared to those in the HFD control group (P < 0.01). FCC supplementation suppressed serum triglyceride and increased serum HDL-C levels (P < 0.01). Serum GOT, GPT and leptin levels, hepatic COX-2 mRNA expression, and splenic COX-2 and IL-4 mRNA expression were significantly higher in the HFD groups than in the control group, without a significant difference in liver weight (P>0.05); however, except for splenic IL-4 levels, these increases were significantly at...
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research