Exploring the frequency and clinical background of the “zebra sign” in amyotrophic lateral sclerosis and multiple system atrophy

In amyotrophic lateral sclerosis (ALS), the “zebra sign” in the precentral gyrus on phase difference enhanced magnetic resonance imaging (PADRE) recently has been reported as a possible imaging biomarker for upper motor neuron (UMN) involvement. A previous study has shown that the “zebra sign” allowed us to differentiate patients with ALS from healthy subjects with excellent accuracy. We validated the usefulness of the sign for differentiating patients with ALS from healthy subjects and investigated whether the “zebra sign” can be observed other neurodegenerative disorders with UMN involvement.

Source: Journal of the Neurological Sciences - April 23, 2019 Category: Neurology Authors: Atsuhiko Sugiyama, Noriko Sato, Yukio Kimura, Yoko Shigemoto, Fumio Suzuki, Emiko Morimoto, Yuji Takahashi, Hiroshi Matsuda, Satoshi Kuwabara Source Type: research