Dopaminergic Therapeutics in Multiple Sclerosis: Focus on Th17-Cell Functions

AbstractMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) with an autoimmune mechanism of development. Currently, one of the most promising directions in the study of MS pathogenesis are the neuroimmune interactions. Dopamine is one of the key neurotransmitters in CNS. Furthermore, dopamine is a direct mediator of interactions between the immune and nervous systems and can influence MS pathogenesis by modulating immune cells activity and cytokine production. Recent studies have shown that dopamine can enhance or inhibit the functions of innate and adaptive immune system, depending on the activation of different dopaminergic receptors, and can therefore influence the course of experimental autoimmune encephalomyelitis (EAE) and MS. In this review, we discuss putative dopaminergic therapeutics in EAE and MS with focus on Th17-cells, which are thought to play crucial role in MS pathogenesis. We suggest that targeting dopaminergic receptors could be explored as a new kind of disease-modifying treatment of MS.Graphical Abstract
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
AbstractMultiple sclerosis is a chronic inflammatory, demyelinating, and neurodegenerative disease affecting the brain, spinal cord and optic nerves. Neuronal damage is triggered by various harmful factors that engage diverse signalling cascades in neurons; thus, therapeutic approaches to protect neurons will need to focus on agents that can target multiple biological processes. We have therefore focused our attention on microRNAs: small non-coding RNAs that primarily function as post-transcriptional regulators that target messenger RNAs and repress their translation into proteins. A single microRNA can target many functio...
Source: Brain - Category: Neurology Source Type: research
ConclusionsOur results might provide fundamentals for the development of new markers of the biological effects of IFN-β therapy.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Current Molecular Medicine - Category: Molecular Biology Authors: Tags: Curr Mol Med Source Type: research
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Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
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