Analysis of the cytotoxic, genotoxic, mutagenic, and pro-oxidant effect of synephrine, a component of thermogenic supplements, in human hepatic cells in vitro.

In conclusion, SN showed no cytotoxic, genotoxic, and mutagenic potential at relevant concentrations for thermogenic users in human hepatic cells in vitro, although, it plays pro-oxidative action, and cytostatic effects. Taken together, our results suggest that other investigations about the hazard absence of this thermogenic compound should be performed. PMID: 31004705 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31004705?dopt=Abstract

Source: Toxicology - April 16, 2019 Category: Toxicology Authors: Ribeiro DL, Machado ART, da Silva Machado C, Dos Santos PW, Aissa AF, Barcelos GRM, Antunes LMG Tags: Toxicology Source Type: research