Markers of maternal cardiac dysfunction in pre-eclampsia and superimposed pre-eclampsia

Women who experience hypertensive disorders of pregnancy have an increased risk of developing cardiovascular diseases including hypertension, stroke, and ischaemic heart disease later in life.1 –3 This risk is evident shortly after an affected pregnancy and persists for decades.4 The mechanism underlying this association is not known, particularly whether women who develop hypertensive disorders are at higher risk pre-pregnancy and pregnancy unmasks their cardiovascular risk, or whether hypertensive disorders of pregnancy are an index event causing cardiovascular damage.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research

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Abbott Laboratories is bringing two of its pediatric devices in the cardiology space to Europe. The Abbott Park, IL-based company has received CE mark for both the Masters HP 15mm rotatable mechanical heart valve and the Amplatzer Piccolo Occluder. The Masters valve is the world's smallest mechanical heart valve and allows doctors to treat babies and toddlers in need of a mitral or aortic heart valve replacement. Until Abbott's device, surgeons could only use a range of larger-sized valves to replace a pediatric heart valve that could not be repaired, which could result in improper fit and complications. The Masters pediat...
Source: MDDI - Category: Medical Devices Authors: Tags: Cardiovascular Source Type: news
Conclusions: Patient and physician-level factors were associated with decision-making regarding extracorporeal membrane oxygenation initiation and withdrawal, including patient prognosis and knowledge of patient or surrogate wishes. Respondents reported low rates of engaging in shared decision-making when managing patients receiving extracorporeal membrane oxygenation.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
CONCLUSION: Human factors, such as chronic health conditions, poor skills and inexperience and poor planning can play a substantial role throughout the chain of events leading to a snorkelling fatality. It is important to educate the community, doctors and dive industry professionals about potential problems associated with the interaction between certain health-related conditions, especially cardiovascular conditions, and snorkelling. Close supervision is strongly recommended for inexperienced snorkellers due to their likely poor skills, as well as for experienced breath-hold divers due to the potential for apnoeic hypoxi...
Source: Diving and Hyperbaric Medicine - Category: Sports Medicine Tags: Diving Hyperb Med Source Type: research
Authors: Mitchell SJ Abstract There are few issues that generate as much confusion in diving medicine as the nomenclature of bubble-induced dysbaric disease. Prior to the late 1980s, the diagnosis 'decompression sickness' (DCS) was invoked for symptoms presumed to arise as a consequence of bubble formation from dissolved inert gas during or after decompression. These bubbles were known to form within tissues, and also to appear in the venous blood (presumably after forming in tissue capillaries). A second diagnosis, 'arterial gas embolism' (AGE) was invoked for symptoms presumed to arise when bubbles were introduce...
Source: Diving and Hyperbaric Medicine - Category: Sports Medicine Tags: Diving Hyperb Med Source Type: research
Publication date: Available online 16 September 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Michael Santostefano, Danuta Herzyk, Diana Montgomery, Jayanthi WolfAbstractTildrakizumab (also known as MK-3222), is a high-affinity, humanized, immunoglobin G1κ monoclonal antibody targeting the p19 subunit of interleukin-23 recently approved for the treatment of moderate to severe plaque psoriasis in the US, Europe, and Australia. The safety profile of tildrakizumab was characterized in nonclinical studies using a pharmacologically relevant cynomolgus monkey model. In repeat-dose toxicity studies, cynomolgu...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
ConclusionsThe costs to achieve one additional ongoing pregnancy with gonadotrophins compared to CC were €21 804 (95%CI, €11 628 to €31 980).Trial registrationNTR 4057
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Publication date: October 2019Source: The Lancet Global Health, Volume 7, Issue 10Author(s): Elizabeth L Prado, Leila M Larson, Katherine Cox, Kory Bettencourt, Julianne N Kubes, Anuraj H ShankarSummaryBackgroundFaltering in linear growth and neurobehavioural development during early childhood are often assumed to have common causes because of their consistent association. This notion has contributed to a global focus on the promotion of nutrition during pregnancy and childhood to improve both conditions. Our aim was to assess whether effects of interventions on linear growth are associated with effects on developmental sc...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: October 2019Source: The Lancet Global Health, Volume 7, Issue 10Author(s): Pedro Ordunez, Ramon Martinez, Patricia Soliz, Gloria Giraldo, Oscar J Mujica, Porfirio NordetSummaryBackgroundThe World Health Assembly 2018 approved a resolution on rheumatic heart disease to strengthen programmes in countries where this condition remains a substantial public health problem. We aimed to describe the regional burden, trends, and inequalities of rheumatic heart disease in the Americas.MethodsIn this secondary analysis of the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2017, we extracted data fo...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: October 2019Source: The Lancet Global Health, Volume 7, Issue 10Author(s): Anirudh Krishnan, Eric Andrew Finkelstein, Per Kallestrup, Arjun Karki, Michael Hecht Olsen, Dinesh NeupaneSummaryBackgroundThe greatest risk factor for cardiovascular disease is hypertension, which can be alleviated via diet, exercise, and adherence to medication. Yet, blood pressure control in Nepal is inadequate, which is partly hindered by a lack of evidence-based, low-cost, scalable, and cost-effective cardiovascular disease prevention programmes. The the community-based management of hypertension in Nepal (COBIN) study was a ...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
CONCLUSION: Women with hypertensive disease of pregnancy have increased mortality risk, particularly for Alzheimer disease, diabetes, ischemic heart disease, and stroke. PMID: 27400006 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
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