664 The neurokinin A/NK2R axis controls IL-10 levels to inhibit activation of cutaneous MCs in vitro and in vivo

In this study, we investigated the effects of NKA on IgE-activated bone marrow (BM)MCs and in the murine model of passive cutaneous anaphylaxis (PCA). The addition of NKA to IgE-loaded BMMCS did not affect MC degranulation, but reduced IL-4, IL-6 and IL-13 transcription.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Neuro-Cutaneous Biology and Inflammation Source Type: research