Quantitative, Label ‐Free Proteomics in the Symptomatic Niemann–Pick, Type C1 Mouse Model Using Standard Flow Liquid Chromatography and Thermal Focusing Electrospray Ionization

In this study, alterations are observed in proteins related to fatty acid homeostasis, calcium binding and regulation, lys osomal regulation, and inositol biosynthesis and metabolism, as well as signaling by Rho family GTPases. New observations from this study include altered expression of Pcp2 and Limp2 in Npc1 mutant mice relative to control, with Pcp2 exhibiting multiple isoforms and specific to the cerebella. This s tudy provides valuable insight into pathways altered in the late‐stage pathophysiology of NPC1.

Source: Proteomics - April 17, 2019 Category: Biochemistry Authors: Melissa R. Pergande, Thu T. A. Nguyen, Carol Haney ‐Ball, Cristin D. Davidson, Stephanie M. Cologna Tags: Research Article Source Type: research