Synthesis and biological evaluation of indole-3-carboxamide derivatives as antioxidant agents

Publication date: Available online 17 April 2019Source: Chinese Chemical LettersAuthor(s): Erfang Huang, Lan Zhang, Chuying Xiao, Guangpeng Meng, Bingqi Zhang, Jianshu Hu, David Chi-Cheong Wan, Qingguo Meng, Zhe Jin, Chun HuABSTRACTOxidative stress results in various pathologies and as consequence antioxidant agents have attracted uninterrupted attention. In this paper, a novel series of indole-3-carboxamide derivatives (6a–6l) were designed and synthesized based on the melatonin structure as novel antioxidants. All of them were evaluated for the antioxidant activities in vitro against human neuroblastoma SH-SY5Y cell line using H2O2 radical scavenging assay. The target compounds 6a, 6f and 6i indicated better activities than the positive control, ascorbic acid, and 6a exhibited the best antioxidant activity. In addition, the structure-activity relationships of the target compounds were also preliminarily summarized based on the obtained experimental data.Graphical abstractA novel series of indole-3-carboxamide derivatives (6a–6l) have been designed, synthesized and evaluated for their antioxidant activity against human neuroblastoma SH-SY5Y cell line using H2O2 radical scavenging assay. Biological activity evaluation showed that compounds 6a, 6f and 6i exhibited significant in vitro activities, which could have the potential to be developed for novel antioxidants.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research