Gut Brain Axis

Helicobacter pylori Induced Anxiety and AnorexiaOurPGP9.5 was used as a Hypothalamic Neuronal Marker in this study-Hajime Suzuki, Koji Ataka, Akihiro Asakawa, Kai-Chun Cheng, Miharu Ushikai, Haruki Iwai, Takakazu Yagi, Takeshi Arai, Kinnosuke Yahiro, Katsuhiro Yamamoto, Yoshito Yokoyama, Masayasu Kojima, Toshihiko Yada, Toshiya Hirayama, Norifumi Nakamura&Akio Inui (2019).Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice. Scientific Reports volume 9, Article number: 6011.Images: Ucn1- and DAPI-positive cells (yellow arrow heads), or Ucn1- and PGP9.5-positive cells (white arrow heads) in the PVN cells.This is the first study demonstrating the anorexigenic and anxiogenic effects of VacA. The authors propose the following. VacA secreted by Hp in the stomach travels via the peripheral circulation and passes through the BBB. VacA binds to LRP1 and activates the intracellular PLC-PKC pathway, resulting in the activation of Ucn1-positive neurons, such as in the PVN of the hypothalamus. Secreted Ucn1 induces the inhibition of food intake through CRF2 receptors and anxiety through CRF1 receptors (Fig. 6). The central Ucn1-CRF receptor axis activated by VacA might be a new important pathway that contributes to the anorexigenic and anxiogenic effects of Hp infection and could be a therapeutic target for Hp-induced alterations.
Source: Neuromics - Category: Neuroscience Tags: Gut-Brain Axis. Hypothalamus Helicobacter pylori Hypothalamic Neurons PGP9.5 Antibody Protein Gene Product 9.5 Source Type: news

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This study examined the relationship of living environment (urban vs. suburban vs. small-town/rural) to social anxiety (SA) in a sample of 902 TGNC individuals who participated in the Trans Health Survey. Analysis of variance revealed a significant difference in SA across living environments. Those living in small-town/rural environments reported significantly higher levels of SA compared to those living in urban environments. There was a trend-level difference in SA in suburban compared to urban environments. Linear regression analyses revealed that living environment significantly moderated the relationship between socia...
Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
Conclusion: Our findings might indicate that the comorbidity of SeAD with SAD may increase the risk of the severity of AvPD and current depression. PMID: 31322453 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
In this study, we characterized the clinical features of SFTS in cats and their associated risk factors, by evaluating the clinical parameters retrospectively. A phylogenetic analysis on SFTSV was also conducted. There were no obvious tendencies in age or sex, outdoor cats were commonly at risk of SFTSV infection. All infected cats showed acute onset of clinical signs including anorexia and lethargy, while 68.2% of the cats showed fever and 41.7% showed vomiting. The case fatality rate was 62.5%. Thrombocytopenia, leukopenia, and elevated serum total bilirubin, serum amyloid A, and creatinine phosphokinase concentration we...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Authors: Tseilikman V, Dremencov E, Tseilikman O, Pavlovicova M, Lacinova L, Jezova D Abstract Glucocorticoid signaling is fundamental in healthy stress coping and in the pathophysiology of stress-related diseases, such as post-traumatic stress disorder (PTSD). Glucocorticoids are metabolized by cytochrome P450 (CYP) as well as 11-β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and 2 (11βHSD2). Acute stress-induced increase in glucocorticoid concentrations stimulates the expression of several CYP sub-types. CYP is primarily responsible for glucocorticoid metabolism and its increased activity can resu...
Source: Stress - Category: Research Tags: Stress Source Type: research
Authors: Mamun MA, Hossain MS, Siddique AB, Sikder MT, Kuss DJ, Griffiths MD Abstract Problematic Internet Use (PIU) has become a concern for public mental health across the globe. However, there are few studies assessing PIU in Bangladesh. The present cross-sectional study estimated the prevalence rate of PIU and its associated risk factors among 405 university students in Bangladesh between June and July 2018. The measures included sociodemographic questions, internet and health-related variables, the Internet Addiction Test (IAT) and the Depression, Anxiety and Stress Scale (DASS-21). The prevalence of PIU was 3...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
MicroRNA‑140 suppresses Helicobacter pylori‑positive gastric cancer growth by enhancing the antitumor immune response. Mol Med Rep. 2019 Jul 08;: Authors: Zhao M, Liu Q, Liu W, Zhou H, Zang X, Lu J Abstract Immune checkpoint blockade is a promising therapeutic strategy against various human malignancies. MicroRNAs (miRNAs/miRs) regulate gene expression, by repressing mRNA translation or promoting its degradation. The aim of the current study was to investigate the role and molecular mechanisms of miR‑140 in Helicobacter pylori (Hp)‑associated gastric cancer, and to examine its relationship with...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Publication date: 20 July 2019Source: New Scientist, Volume 243, Issue 3239Author(s): Jessica Hamzelou
Source: New Scientist - Category: Science Source Type: research
Conclusions: This study highlights the need for more research and interventions for one of the fastest growing subgroups within the TBI population. PMID: 31322004 [PubMed - as supplied by publisher]
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
Ever since I was diagnosed with bipolar disorder in 1991, I’ve struggled with my weight. At that time, I weighed 125 and was prescribed lithium to control my highs and lows. The drug worked, but it and other psychotropic drugs contributed to a 20-pound weight gain. Then, as the years went by, I gained the weight that comes with aging. By 40, I weighed about 180. On a 5’3″ frame, this was a lot to carry. I gained even more weight when I struggled with breast cancer in my late 40s and 50s. At 56, I weighed a cool 188 with no clothes on. Recently, I gained even more (I contribute this gain to simply overindu...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anorexia Children and Teens Eating Disorders Habits Health-related Parenting Personal Adolescence Diet Food Addiction Lithium Weight Gain Source Type: blogs
Stereotypes about men and women have seen massive changes in the last 70 years. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Intelligence subscribers-only Source Type: blogs
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