CGRP and the Trigeminal System in Migraine.

CONCLUSIONS: CGRP plays an essential role in the pathophysiology of migraine. Treatments that interfere with the functioning of CGRP in the peripheral trigeminal system are effective against migraine. Blocking sensitization of the trigeminal nerve by attenuating CGRP activity in the periphery may be sufficient to block a migraine attack. Additionally, the potential exists that this therapeutic strategy may also alleviate cluster headache as well. PMID: 30982963 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30982963?dopt=Abstract

Source: Headache - April 13, 2019 Category: Neurology Authors: Iyengar S, Johnson KW, Ossipov MH, Aurora SK Tags: Headache Source Type: research